International Study Reveals Glyphosate Weed Killers Cause Multiple Types of Cancer

Taylor Thomas — Fri, 20 Jun 2025 23:21:21 +0000

International Study Reveals Glyphosate Weed Killers Cause Multiple Types of Cancer Taylor Thomas Fri, 06/20/2025 - 19:21

In This Story

Melissa J. Perry, Sc.D., MHS, MBA

A comprehensive carcinogenicity study on the world’s most used herbicide, glyphosate, involving scientists from Europe and the U.S., has found that low doses of the controversial weed killer cause multiple types of cancer in rats.

In this long-term study, published on Tuesday, glyphosate alone and two commercial glyphosate-based formulations, Roundup BioFlow (MON 52276) used in the EU and Ranger Pro (EPA 524-517) used in the U.S., were administered to rats via drinking water beginning in prenatal life, at doses of 0.5, 5, and 50 mg/kg body weight/day for 2 years. These doses are currently considered safe by regulatory agencies and correspond to the EU Acceptable Daily Intake (ADI) and the EU’s No Observed Adverse Effect Level (NOAEL) for glyphosate.

In all 3 treatment groups, increased incidences of benign and malignant tumors at multiple anatomic sites were observed compared to controls. These tumors arose in haemolymphoreticular tissues (leukemia), skin, liver, thyroid, nervous system, ovary, mammary gland, adrenal glands, kidney, urinary bladder, bone, endocrine pancreas, uterus and spleen (hemangiosarcoma). Increased incidences occurred in both sexes. Most of these involved tumors that are rare in Sprague Dawley rats (background incidence < 1%) with 40% of leukemias deaths in the treated groups occurring in early life and increased early deaths were also observed for other solid tumors.

“We observed early onset and early mortality for a number of rare malignant cancers, including leukemia, liver, ovary and nervous system tumors. Notably, approximately half of the deaths from leukemia seen in the glyphosate and GBHs treatment groups occurred at less than one year of age, comparable to less than 35-40 years of age in humans. By contrast, no case of leukemia was observed in the first year of age in more than 1600 Sprague Dawley historical controls in carcinogenicity studies conducted by the Ramazzini Institute and the National Toxicology Program (NTP),” stated Dr. Daniele Mandrioli, Director of the Cesare Maltoni Cancer Research Center of the Ramazzini Institute and Principal Investigator of the study.

The multi-institutional Global Glyphosate Study is being led by the Cesare Maltoni Cancer Research Center of the Ramazzini Institute in Italy and involves scientists from Boston College, 91��, King’s College London, Icahn School of Medicine at Mount Sinai, Scientific Centre of Monaco, University of Bologna, the Institute of Agricultural Biology and Biotechnology of the Italian National Research Council, the Italian National Institute of Health and the National Food Safety Committee of the Italian Ministry of Health.

The Cesare Maltoni Cancer Research Center of the Ramazzini Institute, with over 200 compounds studied in over 50 years, is the largest bioassay program in the EU: vinyl chloride, asbestos, benzene and radio frequencies are amongst the carcinogenic agents that have been investigated in its laboratory. Most recently, the Cesare Maltoni Cancer Research Center of the Ramazzini Institute also published a peer-reviewed report in collaboration with the U.S. National Institute of Environmental Health Sciences (NIEHS) on the toxicological effects of nicotine.

These new results provide robust evidence supporting International Agency for Research on Cancer’s (IARC) conclusion in 2015 that there is “sufficient evidence of carcinogenicity of glyphosate in experimental animals”. Furthermore, the study’s data are consistent with epidemiological evidence on the carcinogenicity of glyphosate and glyphosate-based herbicides.

“Our findings reinforce IARC’s classification of glyphosate as a probable human carcinogen and are consistent with experimental animal studies as well as human correlational and weight-of-evidence evaluations that have reported associations between glyphosate exposure and certain cancers, particularly hematological malignancies,” said Dr. Melissa Perry, study co-author and Environmental Epidemiologist at 91�� College of Public Health.

The Global Glyphosate Study is the most comprehensive toxicological study ever conducted on glyphosate and glyphosate-based herbicides. It aims to provide vital data for government regulators, policy makers and the general public. The study is examining the impacts of glyphosate and glyphosate-based herbicides on carcinogenicity, neuro-developmental toxicity, multi-generational effects, organ toxicity, endocrine disruption and prenatal developmental toxicity.

“This robust study, based on a protocol encompassing pre- and post-natal development, fulfills the need for sound scientific evidence on the toxicology of glyphosate. The results highlight the tumorigenic potential of glyphosate and glyphosate-based products at dose levels considered as “safe”. This new evidence has to be carefully considered by the regulatory authorities globally,” added Dr. Alberto Mantovani, study co-author and member of the Italian National Food Safety Committee (CNSA).

The GGS’s findings on glyphosate’s toxicity to the microbiome, which were peer-reviewed and published in late 2022 and presented at the EU Parliament in 2023, also showed adverse effects at doses that are currently considered safe in the EU (0.5 mg/kg bw/day, equivalent to the EU Acceptable Daily Intake).

The GGS also previously published a pilot study, which showed endocrine and reproductive toxicity in rats at glyphosate doses currently considered safe by regulatory agencies in the U.S. (1.75 mg/kg bw/day). These findings were later confirmed in a human population of mothers and newborns exposed to glyphosate during pregnancy.

The next step in the GGS will be the neurotoxicity arm, which is vital for understanding any role glyphosate and glyphosate-based herbicides may be playing in the rise of neurological related diseases and disorders.

“The findings from this carefully conducted study, and especially the observation that prenatal exposures of infant rats to glyphosate during pregnancy increase incidence and mortality from early-life leukemia, is a powerful reminder of human infants’ great vulnerability to toxic chemicals and strong reason to eliminate glyphosate from the production of foods consumed by pregnant women and their children,” concluded Dr. Philip Landrigan, study co-author and Director of the Program for Global Public Health and the Common Good at Boston College.

This was originally posted on glyphosatestudy.org. Full paper can be found here.

Topics

cancer research

Cancer Prevention and Control

Environmental Epidemiology

Epidemiology

Research

pesticides

New study finds association between insecticide exposure and lower sperm concentration in adult men

mthomp7 — Tue, 14 Nov 2023 22:30:37 +0000

New study finds association between insecticide exposure and lower sperm concentration in adult men mthomp7 Tue, 11/14/2023 - 17:30

In This Story

Melissa J. Perry, Sc.D., MHS, MBA

Media Inquiries Learn More

Comprehensive systematic review of 25 studies over 25 years reveals consistent evidence of associations between insecticide exposure and lower sperm concentration

In a new systematic review, Melissa J. Perry, Sc.D., MHS, dean of the 91�� College of Public Health, and Lauren Ellis, MPH, doctoral student at Northeastern University, found that there is a strong association between insecticide exposure and lower sperm concentration in adult men globally.

“Understanding how insecticides affect sperm concentration in humans is critical given their ubiquity in the environment and documented reproductive hazards. Insecticides are a concern for public health and all men, who are exposed primarily through the consumption of contaminated food and water,” says Ellis.

The team reviewed decades of human evidence regarding the health impacts of exposure to two widely used insecticide classes, organophosphates and N-methyl carbamates, and found consistent associations with lower sperm concentration, which warrants concern, particularly in light of observed downward trends in semen quality demonstrated by other studies.

“This review is the most comprehensive evidence sizing up more than 25 years of research on male fertility and reproductive health. The evidence available has reached a point that we must take regulatory action to reduce insecticide exposure,” says Dr. Perry, the senior author on the paper.

The research team systematically reviewed 25 human studies of occupational and environmental insecticide exposure conducted over the course of 25 years. To the reviewers’ knowledge, this is the most comprehensive systematic review on this topic to date, and the first to use these methods to quantitatively synthesize decades of epidemiological literature.

“Adult Organophosphate and Carbamate Insecticide Exposure and Sperm Concentration: A Systematic Review and Meta-Analysis of the Epidemiological Evidence” was published online in Environmental Health Perspectives in November 2023 (DOI is 10.1289/EHP12678). Karen Molina, C. Rebecca Robbins, and Marlaina Freisthler from George Washington University; Daria Sgargi from the Cesare Maltoni Cancer Research Center, Ramazzini Institute; and Daniele Mandrioli from the University of Bologna are additional authors on the paper.

Most of the research was conducted while Perry and Ellis were at George Washington University. There was no outside funding for this research.

Topics

Environmental influences on human fecundity and fertility

Fertility

Reproductive Epidemiology

Research

pesticides