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Brainpower inspires energy-efficient AI

tdonnel — Thu, 22 Jan 2026 16:57:20 +0000

Brainpower inspires energy-efficient AI tdonnel Thu, 01/22/2026 - 11:57

The key to energy-efficient artificial intelligence (AI) could lie in the human brain. 91�� researchers Maryam Parsa (PI) and Giorgio Ascoli (co-PI) are leading a Department of Energy-funded project to make AI dramatically more efficient by mimicking the brain’s computing strategies.

Maryam Parsa. Photo provided.

“AI today is powerful but extremely energy-hungry,” said Parsa, an assistant professor in George Mason’s Department of Electrical and Computer Engineering who specializes in neuromorphic computing. “We want to understand why the human brain is so efficient and why AI is not—and then bridge that gap.”

Unlike traditional AI models that rely on continuous signals and massive data centers, the brain uses sparse, event-driven signals called spikes.

“Any one neuron only fires a spike here and there, but the timing of those spikes carries a lot of meaning,” explained Ascoli, a Distinguished University Professor in George Mason’s Bioengineering Department specializing in neuroscience. “That’s why the brain can do so much with so little energy.”

To replicate this efficiency holistically, Parsa and Ascoli teamed up with Akhilesh Jaiswal at the University of Wisconsin–Madison and Pedram Khalili at Northwestern University. The team is building a full-stack neuromorphic computing system spanning devices, circuits, architectures, algorithms, and applications.

Each principal investigator is contributing specific expertise to the system:

Ascoli contributes neuroscience insights using Izhikevich models, mathematical frameworks that capture real neuron spiking dynamics, to inform system design.
Khalili develops spintronic devices, components that utilize magnetic materials to harness an electron's quantum properties of spin and charge for processing and storing data. By naturally exhibiting neuron-like temporal behavior, these devices are expected to reduce energy demands.
Jaiswal designs analog circuits to integrate these spintronic devices into functional architectures.
Parsa leads the project as well as neuromorphic learning algorithms and application-level integration, exploring diverse learning approaches to optimize speed, precision, resiliency, privacy, and energy savings.

Giorgio Ascoli. Photo provided.

“Izhikevich models allow neuromorphic systems to mimic the timing, diversity, and variability of real neurons, enabling more brain-like learning and efficiency,” Ascoli said. His extensive experience with these models, including simulating hippocampal networks, provides the biological foundation for the project.

“Instead of forcing existing devices to mimic brain behavior, we asked: What if we leverage new devices that naturally exhibit these dynamics?” Parsa said. This approach ensures innovations at the hardware level align with biologically inspired algorithms, creating a cohesive system rather than isolated solutions.

By introducing greater biological complexity and leveraging novel spintronic devices, the team hopes to reduce AI’s energy footprint while improving performance metrics such as accuracy and privacy. Early results are promising; even simple changes to spike distributions improved privacy without sacrificing accuracy.

The research also explores learning algorithms beyond the traditional. “Our goal is to see how different neuron models and learning rules interact and which combinations optimize for speed, precision, or energy savings,” Parsa said.

Ultimately, the project could transform AI by making it greener and more brain-like. “If we succeed, we’ll have systems that learn faster, consume less power, and operate more like the brain,” said Ascoli.

“This is not just about making AI more efficient,” said Parsa. “It’s about rethinking computing from the ground up."

In This Story

Maryam Parsa

Giorgio Ascoli

Explore AI at George Mason

Topics

Electrical and Computer Engineering

Learn more about George Mason's Grand Challenge Initiative

Artificial Intelligence

Department of Energy

C-TASC

Printing play: A path forward for children with prosthetics

Nathan Kahl — Thu, 15 Jan 2026 13:32:50 +0000

Printing play: A path forward for children with prosthetics Nathan Kahl Thu, 01/15/2026 - 08:32

A child who uses a lower-limb prosthesis faces unique challenges when it comes to activities most children take for granted, such as running and being active. Without access to a prosthetic device designed to support these movements, children may miss out not only on the simple joys of play, but also on critical opportunities for physical development during key stages of growth.

Quentin Sanders. Photo by Ron Aira/Office of University Branding

91�� researcher Quentin Sanders is part of a collaborative research team working to make high-performance prosthetic limbs more affordable, accessible, and better tailored to the needs of active children. Sanders, along with Jonathon Schofield, an associate professor at the University of California, Davis, and Garrett Melenka, an associate professor at York University, received a three-year, $500K grant from the National Science Foundation to support the project, which began in September 2025.

Most standard foot or leg prostheses are built for basic walking, not for the kind of active movement that helps children develop strength, balance, and coordination, the benefits that come from running and jumping with friends.

“This limitation can be especially challenging for children,” said Sanders, who has a joint appointment in the Department of Bioengineering and the Department of Mechanical Engineering. “Kids want to run and play. When they can’t, they’re more likely to avoid physical activities, such as sports, or even stop using their prosthesis altogether.”

A 3D-printed running blade prototype, created using the technique Sanders and his colleagues are developing. Photo provided

Often seen in competitive events such as the Paralympic Games, running blades are curved, spring-like prosthetic feet made from carbon fiber that mimic the energy return of a biological foot. While these devices offer an alternative option to standard leg prostheses and can enable children to run, they are expensive and often inaccessible. A single running blade can cost several thousand to tens of thousands of dollars and is typically not covered by insurance because it is considered nonessential, rather than medically necessary.

Some charitable organizations help families access these devices, but demand far exceeds supply, and for growing children, one blade is rarely enough. “Kids grow quickly,” said Sanders. “As they get taller, they outgrow their prostheses, which means going through multiple blades over time.”

The research team has several goals, starting with identifying what children truly need from an activity-enabling prosthesis. The researchers are examining how motivation to be active, physical growth, and different types of movement influence prosthetic performance in everyday settings. “What do you use it for? What don’t you use it for? What do you wish you could do?” said Sanders.

The team is also analyzing how children move while using their current running blades, studying activities such as running, jumping, and changing direction to better understand the biomechanics and physical demands involved.

Finally, the team will take a close look at how today’s running blades perform under real-world demands. “We want to understand how stiff they are, how much load they can handle, and when they might fail,” said Sanders. “We can then combine that information with what kids tell us they want to do and use it to guide our 3D printing process—creating blades that are better suited for active play.”

Sanders and his collaborators are using an advanced additive manufacturing approach known as continuous-fiber 3D printing, in which carbon fibers are embedded within the printed plastic to reinforce the prosthetic structure. This method enables the creation of strong, lightweight devices that can be tailored to a child’s size, growth, and activity needs.

“By combining manufacturing, composite materials, prosthetics, design, and biomechanics, this project provides an innovative and holistic solution,” said Melenka.

The technique is already used to produce strong, lightweight components in the aerospace and automotive industries, but it has seen limited adoption in prosthetic design. This project represents one of the first efforts to apply it systematically to activity-enabling prostheses for children.

“What’s most exciting about this project is the collaboration across institutes, disciplines, and areas of expertise,” said Schofield. “We are bringing together researchers in movement mechanics, advanced materials manufacturing, and pediatric lower-limb prosthetic care. We are also incorporating the lived experience of children and families, along with clinicians who work with these patients every day.”

The work also has the potential for industry disruption, according to Sanders. “If we can show that a child’s physical measurements and movement needs can be translated into a digital model and then used to 3D print a customized prosthesis, existing prosthetic manufacturers would begin to integrate this approach into their production pipelines.”

For Sanders, the motivation goes beyond technical innovation. “I’ve always been interested in translating new technologies into real-world solutions,” he said. “Helping people with disabilities and impairments is why I got into this field in the first place.”

In This Story

Quentin Sanders

Topics

mechanical engineering

3D Printing

National Science Foundation

Fuse at Mason Square

GCI-Health

GCI-Grand Challenge Initiative

George Mason team earns $2.1M to study seizure dynamics

tdonnel — Tue, 13 Jan 2026 15:06:52 +0000

George Mason team earns $2.1M to study seizure dynamics tdonnel Tue, 01/13/2026 - 10:06

In This Story

John Cressman

Parag Chitnis

Remi Veneziano

The National Institutes of Health (NIH) awarded a 91�� research team $2.1 million to create a system that could revolutionize the study of seizures.

The project combines the expertise of Parag Chitnis and Remi Veneziano (Department of Bioengineering), and Rob Cressman (Department of Physics and Astronomy) to develop an imaging and sensing system for identifying areas of the brain with potassium ion dysregulation.

“Potassium is one of those ions that actually inhibits activation of cells. If there's a dysfunction in those ions, you get runaway signaling. A seizure is an example of that,” said Cressman, who has studied epilepsy since his postdoctoral work. “We’re trying to develop tools that help us understand that better.”

From left, Parag Chitnis, Rob Cressman, and Remi Veneziano. Photo by Evan Cantwell/Office of University Branding.

When the biocompatible nanosensors, made of DNA and light-sensitive dye, encounter a local change in potassium concentration, they change their shape resulting in a change in their near-infrared fluorescence signal.

“We want to detect even very small changes in potassium,” said Veneziano, whose work involves synthesizing new nanomaterials from DNA particles, proteins, and lipids. “The system we’ve built is modular, versatile, and highly sensitive.”

These signals can be mapped in real-time using a near-infrared imaging device to understand dynamic changes in ion concentration.

One of the most promising applications is image-guided surgical intervention for epilepsy. By pinpointing seizure foci through potassium mapping, surgeons may be able to perform precise tissue ablation, removing only the affected areas.

“If you can identify the focus and remove that part of the tissue, you can sometimes stop the seizures,” said Cressman.

The four-year NIH-funded project, previously funded by the National Science Foundation (NSF), builds on years of research supported by George Mason’s Center for MedTech Innovation.

“This grant allows us to translate our NSF-funded feasibility work into real-world applications,” said Chitnis, who studies brain-body interactions using light and ultrasound. “We’re not just studying disease—we’re building tools that could guide future interventions.”

The toolkit will be tested across multiple platforms—from cell cultures to brain slices to intact mammalian models—allowing researchers to study bioelectrical activity at various scales.

The team also sees potential for assessing functional recovery after traumatic brain injury. Scar tissue can disrupt potassium regulation, and the nanosensors may help identify regions at risk of developing seizure foci. As the research progresses, the team hopes to open new pathways for understanding and treating complex brain disorders.

Topics

College of Science

National Science Foundation

National Institutes of Health

Students S.E.R.V.E. those who have served

Jennifer Pocock — Tue, 28 Oct 2025 20:47:53 +0000

Students S.E.R.V.E. those who have served Jennifer Pocock Tue, 10/28/2025 - 16:47

91�� students take third in competition to help veterans maintain their quality of life.

Team 7 shows their prosthetic liner solution after winning third place at the Project S.E.R.V.E. National Design Competition. From left, Kunaal Jindal (student), Steve McMillian (Project S.E.R.V.E. Northeast Program Manager), Cassidy Worzalla (student), Dibyashree Basu (student), Shani Ross (senior design instructor), and Gabriel Gibson (student). Photo provided

Miami-based nonprofit Project S.E.R.V.E. (Student Engineering for Resilience of Veterans and Emergency Responders) helps wounded responders get back on their feet and gives bioengineering students valuable hands-on experience in the prosthetics field at the same time. It has sponsored prosthetic limbs for more than 1,300 veterans and first responders from more than 2,000 students since its founding in 2009.

In May, the nonprofit (formerly known as Quality of Life Plus) brought eight teams together for a national competition in Blacksburg, Virginia. Universities from Ohio, Florida, New Jersey, and Virginia gathered to see who could design a prosthetic socket and liner that would mitigate heat and moisture for lower limb amputees.

George Mason’s team comprised Gabriel Gibson, Cassidy Worzalla, Dibyashree Basu, and Kunaal Jindal, all bioengineering majors. Over the course of two semesters, they developed, tested, and evaluated multiple prototypes. They also had to present their progress and proposed solutions twice in fall and once in spring to a group of stakeholders, including prosthetic wearers, for feedback. 

On May 3, the day of competition, Team 7 presented their solution: a silicone liner made with a thermal conductive polymer and containing moisture-absorbent strips. They were judged on two different real-time tests: how much the design lowered the temperature, and how the design helped control temperature and humidity levels when a test subject performed a physical activity.

“The judges liked the innovative design and thought their idea was creative and promising,” said Shani Ross, the senior design instructor and bioengineering associate professor. “We are very proud of the work that the team did. They showed ingenuity, tenacity, and teamwork and represented 91�� well.” 

Their product helped them take third place—and contributed to the science of prosthetics, and a better quality of life for affected heroes.  

In This Story

Shani Ross

Topics

competitions

Veterans

Forged in passion, not just fire: This alum is on a hot streak

sbrown79 — Mon, 27 Oct 2025 18:20:46 +0000

Forged in passion, not just fire: This alum is on a hot streak  sbrown79 Mon, 10/27/2025 - 14:20

Keeping his nose to the grindstone is not just how Andrew Hutsell approaches his academic career in engineering—it's how he cut a small slice of fame.  

The 91�� alumnus recently put his engineering skills to the test on national television, competing in an episode of the History Channel’s Forged in Fire, a competition show that challenges bladesmiths to create weapons under tight deadlines.  

Hutsell (second from right) and the Forged in Fire judges. Photo provided.

Hutsell, BS Mechanical Engineering ’23, appeared on the episode “Junkyard Meltdown” on September 17 (S10E27).  

 Hutsell’s journey began when one of the show’s judges posted a casting call on Instagram.  

“I was still a student at the time, so they asked what I do at George Mason, what I do in my free time, and to provide examples of the knives I’ve made,” said Hutsell, who also was president of George Mason’s club baseball. 

Hutsell has been a fan of the show since 2016 and started bladesmithing in 2019.  

“Ever since I started making knives, I have only had one goal with each knife I make: learn at least one new skill or method [for the trade]. With this mindset, it is easy to see how my skills have improved over time,” said Hutsell. 

After multiple rounds of interviews, he got the call to appear during a midterm exam.  

Filming took place in March and April 2023. Hutsell described the show’s format as similar to Chopped, but instead of cooking, contestants forge knives through three rounds of competition.  

One of Andrew Hutsell's knives. Photo provided.

For the last round, judges pick a historical weapon, such as a broad sword or katana, and then contestants go back to their hometown to forge it with their own equipment.   

"I traveled back home to Newport News. When I came back, they tested it to determine the winner,” said Hutsell.  

“They tested the knives by chopping through bone for strength, then slicing sugar cane to see how well the edge held up. It was surreal to compete on a show I’d watched for years,” said Hutsell, who came in second place.  

Hutsell is currently a graduate student at Virginia Commonwealth University working on similar topics such as fluids research.  

“The research that I’m doing is for thermal hydraulics—the cooling system—of molten salt [nuclear] reactors, researching the gas sparring of fission products of molten salts for molten salt reactors,” said Hutsell.  

Hutsell was influenced by Jeffrey Moran, an assistant professor in the Department of Mechanical Engineering, who Hutsell describes as a “a big influence on my work with heat and mass transfer,” as well as Juan Cebral, an associate professor in the Department of Bioengineering.  

“It is always very rewarding when a student demonstrates this passion for learning and dedicates substantial time and effort to master the material to reach high levels of achievement,” said Cebral. “Andrew was one of those students who is dedicated to solving complex problems. His perseverance and motivation will certainly help him make important contributions in his field.”  

Connect with the Alumni Association

In This Story

Juan Cebral

Jeffrey Moran

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Alumni

mechanical engineering

competitions

Expanded BioE Buzz summer camp brings high schoolers to life sciences

Jennifer Pocock — Tue, 21 Oct 2025 17:56:23 +0000

Expanded BioE Buzz summer camp brings high schoolers to life sciences Jennifer Pocock Tue, 10/21/2025 - 13:56

New offerings and a healthy dose of competition left campers happily humming along.

BioE Buzz students work on a polymer testing challenge at the 2025 summer camp. Photo provided.

When the 2024 BioE Buzz camp was declared a success, the 91�� organizers used the momentum to level up in 2025. Its inaugural year boasted one week of experiments, tours, lectures, and activities for 16 high school juniors and seniors.

This past summer, however, introduced a new element that lit the fire for bioengineering-curious kids: competition. Expanded to two one-week sessions for 32 students, the camp’s codirectors Khadija Zaidi-Rashid and Liszt Yeltsin Madruga randomly assigned them into teams.

“We would do lab tours, meet faculty experts, and have seminars in the mornings,” said Zaidi-Rashid, an assistant professor in the Department of Bioengineering in the College of Engineering and Computing. “After lunch, we would separate them into their groups, where they would develop a certain skill and work on a team challenge.”

One day, the kids used 3D printing to model a bone that couldn’t break. The next, they mixed polymers to see which could suspend a steel ball. Another day saw them swabbing campus benches, rocks, and trashcans to find out which would result in the petri dish with the richest bacteria culture.

“They were very creative in working with our parameters,” said Yeltsin Madruga, a research assistant professor in bioengineering. “We told them they could not swab anything biological, like humans. They pushed this by swabbing a bench they saw animals climbing on, or the bottom of a person’s shoe.”

All of the projects were tested live on the final day of camp in front of the campers and parents, where the winners were announced. The prize? A one-week internship in the students’ department of choice.

According to Zaidi-Rashid, both the competition and the prize were huge hits with campers. “At the beginning of the week, we took them to the EDGE ropes course to encourage team development. They were immediately psyched about the competition, asking if they could get points for finishing the course,” she said.

The camp’s hands-on aspect was also motivating. One camper returned for a second year at the urging of his parents. “At first, he wasn’t excited," said Yeltsin Madruga. “He was afraid it would be a repeat from last year. At the end, he came up and told me, ‘I thought it would be an adult’s idea of educational…like lectures.’ He was happy to be wrong!”

And the fact that the reward could help them in their careers and get aspiring bioengineers to take a deeper look at George Mason was a win for campers and the college alike. “Many of the campers arrived on the first day wearing college t-shirts and sweatshirts—and none of them were from Mason,” said Zaidi-Rashid. “On the last day, they were all wearing Mason apparel, and lots of them were interested in our programs because they saw what we could actually offer.”

The most rewarding, however, was helping the kids build community. “On the first day, the students were very quiet. By the end of the camp, they were all very friendly and chatty,” she said. “In high school, it’s hard to know who has your same future aspirations, so it was nice to see them find their people.”

Topics

Summer Camps

K-12 Partnerships

GCI-Grand Challenge Initiative

Biomedical internship yielded lively experience

Jennifer Pocock — Fri, 22 Aug 2025 18:22:51 +0000

Biomedical internship yielded lively experience Jennifer Pocock Fri, 08/22/2025 - 14:22

Jacob Lockey improved his pipette and professional skills in his summer at Athari Biosciences.

Jacob Lockey (right) with his Athari Biosciences mentors, Sanskruthi Sreepangi (middle) and Mahaniya Srinivasan (left).

When Lockey, a bioengineering major through the bachelor’s accelerated master’s program at 91��, accepted his internship at Athari Biosciences, he knew that he would have a different experience than his fellow students at larger companies.

Athari is a small health equity accelerator lab in Sterling, Virginia, that performs biomedical R&D, lab testing, and educational services. Lockey is interested in nanomedicine, especially researching nanocarriers.

“A nanocarrier is a nanoparticle that has been engineered to hold something—in some cases, a drug—and deliver it to a target, such as a cancer cell,” he said. “The internship was very useful for stuff I’d be doing in the future.”

Lockey worked on several different projects, including helping calibrate a robot that automates assays (experiments or tests). He also optimized and built different assays, including one using E. coli bacteria to see how it would react to novel antibacterial drugs. This allowed him to explore options for new drugs that could not only kill E. coli bacteria but also make it less likely to become drug resistant.

“My favorite part overall was the last day,” he said. “Athari hosted a friends and family presentation day. We got to present our work in what would be a real scientific setting, but it was with the C-suite at Athari and our friends. It was the culmination of everything we did at the company all at once.”

Lockey said that George Mason prepared him “a million percent” for the internship through both his technical classes and the soft skills he gained during group work and hands-on projects. “The biggest thing I’ve gotten from school was approaching problem solving and thinking like an engineer. Going from an academic setting to a corporate setting, Mason did a great job in helping us get there.”

And when he got there, the experience was top-notch. “Athari was very warm and welcoming,” he said. “Taking on interns is a big lift for a small company, but they put a huge emphasis on training and developing the next generation. I learned tons of new skills that I didn’t think I’d get to learn.”

Some of these included wet lab experience, assay development, and testing. Not to mention pipette work. “I have shaky hands and they really helped me. By the end, I was pipetting like a pro.”

Topics

CEC internships

Biomedical

internships

CEC students

Bioengineering students spend the summer exploring career pathways at AstraZeneca

Jennifer Pocock — Thu, 14 Aug 2025 17:35:31 +0000

Bioengineering students spend the summer exploring career pathways at AstraZeneca Jennifer Pocock Thu, 08/14/2025 - 13:35

George Mason prepared students for real-world experiences ahead of their senior years.

Ayham Elayan (top) and Eileen Robles (bottom) spent their summers gaining professional experience. Photos provided.

Ayham Elayan and Eileen Robles, bioengineering students graduating from 91��’s College of Engineering and Computing in December, spent their summer breaks at AstraZeneca—one in operations, and one in the lab. Their experiences demonstrate two of many possible paths in bioengineering.

Elayan is interested in entering the biotech industry when he graduates this winter. He went to AstraZeneca hoping to explore different aspects of the pharmaceutical industry and ended up working on the tech transfer team.

“My team was responsible for the transfer of knowledge of drug manufacturing between sites. If AstraZeneca wants to open a new manufacturing site, for example, we figure out what action or equipment needs to be taken or installed,” he said. “We also make sure that the equipment works and is standardized and nothing affects the medication quality.”

Elayan said that the experience taught him just how many different teams and steps it takes to get reliable drugs to the public. “There were two best parts of the internship. The first was taking my first steps into the industry and getting a lot of exposure and experience,” he said. “The second was meeting so many different people with tons of experience that they shared with me. It’s a global company and I’ve gotten to work with people from around the world.”

Robles’s experience was less strategic and more hands-on, which excited her. “Bioengineering is such a broad field with so many different pathways,” she said. “It was great to experience something you can’t learn in a classroom.”

She interned in a wet lab, working on improving methods to purify a specific protein used in medicines. “I compared two different resins that help capture the protein, tested them for unwanted contaminants, and analyzed the results. The goal was to figure out which resin would work best for making the purification process more efficient, helping ensure future medications are safe and effective.” She said that she hasn't worked on much faculty-led lab research in during her degree program, so the internship expanded her interests and confirmed that "I value hands-on experience.”

Robles said George Mason was helpful in preparing her not just through relevant classwork, but also by assigning hands-on group work. “That [team work] really helped me to work in this type of environment where you have to collaborate with different people,” she added.

Both Robles and Elayan emphasized that the professional teams they joined were supportive and made them excited for life after graduation. “Everyone there really respects each other and wants to help you out,” Robles said. “I spoke to employees who have moved between different roles. It helped me approach my career with more flexibility and less pressure to find the perfect job immediately.”

Topics

CEC internships

internships